| Variant | Significance | Condition | Review Status | Last Evaluated |
|---|---|---|---|---|
| NM_000130.5(F5):c.1601= (p.Arg534=) | Conflicting classifications of pathogenicity | not provided; Congenital factor V deficiency | criteria provided, conflicting classifications | 2025/02/04 00:00 |
| NM_198578.4(LRRK2):c.6055G>A (p.Gly2019Ser) | Pathogenic/Likely pathogenic; risk factor | Young-onset Parkinson disease; Inborn genetic diseases; not provided; Parkinson disease; Autosomal dominant Parkinson disease 8; Parkinson disease, late-onset | criteria provided, multiple submitters, no conflicts | 2025/11/12 00:00 |
| NM_000130.4(F5):c.1601G>A (p.Arg534Gln) | drug response | hormonal contraceptives for systemic use response - Toxicity | reviewed by expert panel | 2021/03/24 00:00 |
| NCT ID | Title | Phase | Status | Sponsor |
|---|---|---|---|---|
| NCT05233384 | Genomics of Fibrin Clot Structure in Patients With Constitutional Dysfibrinogenemia | Not specified | ACTIVE_NOT_RECRUITING | University Hospital, Clermont-Ferrand |
| NCT04351412 | Comparison of Dentin Hypersensitivity Reduction Over a 1-month Period Between a Single Topical Application of a Dentin-desensitizing Agent (Gluma) and Other Materials: A Randomized Clinical Trial | NA | COMPLETED | King Abdulaziz University |
| NCT01838863 | A Prospective, Randomized Comparison of Fresh Frozen Plasma Versus Standard Crystalloid Intravenous Fluid as Initial Resuscitation Fluid | PHASE2 | TERMINATED | Denver Health and Hospital Authority |
| NCT00910650 | Adoptive Transfer of MART-1 F5 TCR Engineered Peripheral Blood Mononuclear Cells (PBMC) After a Nonmyeloablative Conditioning Regimen, With Administration of MART-126•35-Pulsed Dendritic Cells and Interleukin-2, in Patients With Advanced Melanoma | PHASE2 | COMPLETED | Jonsson Comprehensive Cancer Center |
| NCT00509288 | Phase II Study of Metastatic Melanoma Using Lymphodepleting Conditioning Followed by Infusion of Anti-MART-1 F5 TCR-Gene Engineered Lymphocytes | PHASE2 | COMPLETED | National Cancer Institute (NCI) |
| NCT05748808 | Use of Biofeedback and Virtual Reality as Facilitators of Emotional Recognition in the Treatment of Aggressive Outbursts | NA | RECRUITING | University of Seville |
| NCT07290907 | EFFECTIVENESS OF HOME-BASED CARDIAC REHABILITATION TO IMPROVE QUALITY OF LIFE AND HEALTH BEHAVIOR OF PATIENTS WITH CARDIOVASCULAR DISEASES IN LOW-RESOURCE SETTINGS IN PAKISTAN | NA | NOT_YET_RECRUITING | Pakistan Institute of Medical Sciences |
| NCT03054129 | Efficacy of Balance Training in Patients With Rotator Cuff Disease: A Randomized Controlled Trial | NA | COMPLETED | Dokuz Eylul University |
| NCT05534945 | Programmed Intermittent Epidural Bolus for Postoperative Analgesia After Laparotomy: Determining the Optimum Dose Using a Biaised Coin Up-and-down Sequential Allocation Protocol | NA | RECRUITING | Ciusss de L'Est de l'Île de Montréal |
| NCT05621057 | Augmentative Affective Interface (AAI): Evaluation Methodology of Emotional States for People With Cerebral Palsy | Not specified | ACTIVE_NOT_RECRUITING | University of Seville |
| NCT00706992 | Transfer of Autologous T Cells Transduced With the Anti-MART-1 F5 T Cell Receptor in High Risk Melanoma | PHASE2 | TERMINATED | National Cancer Institute (NCI) |
| NCT06385405 | Repetitive Transcranial Magnetic Stimulation(rTMS) Treatment Based on Personalized Modulation of Electroencephalography Promotes Symptom Remission in Major Depressive Disorder (MDD) - A Randomized Controlled Clinical Trial | NA | RECRUITING | Shanghai Mental Health Center |
| NCT01054586 | HI FPV Study: Using Observational Cohorts to Monitor Safety of Fosamprenavir in Patients With Mild/Moderate Hepatic Impairment | Not specified | COMPLETED | GlaxoSmithKline |
| NCT06885814 | A Phase II Clinical Study on the Efficacy and Safety of Adebrelimab Combined With Chemoradiotherapy in Patients With Unresectable Locally Advanced or Postoperative Recurrent Esophageal Squamous Cell Carcinoma | PHASE2 | RECRUITING | Nanfang Hospital, Southern Medical University |
| NCT00888511 | Concomitant Tarceva® and Irradiation in Patients in Local-regionally Advanced Non-small Cell Lung Cancer. A Phase II Study | PHASE2 | COMPLETED | Olfred Hansen |
| NCT06771362 | Evaluation of ART Restorations Using Two Different Bulk-Fill Restorative Materials in Primary Molars With 12-month Follow-up According to Modified USPHS and Revised FDI Criteria | NA | COMPLETED | Çanakkale Onsekiz Mart University |
| NCT00107653 | A Prospective, Multicenter, Open-label, Comparative, Efficacy Study of Pegasys® Plus Copegus® in Treatment-naïve Latino Patients With Chronic Hepatitis C-genotype 1, as Compared to Treatment-naïve Non- Latino Caucasian Patients With Chronic Hepatitis C-genotype 1 | PHASE4 | COMPLETED | Hoffmann-La Roche |
| NCT06991842 | Effect of Phosphoric Acid Etching Duration on the Performance of Direct Resin-Based Composite Restorations in Permanent Anterior Teeth: A Randomized Controlled Single-Center Trial | NA | RECRUITING | Florin Eggmann |
| NCT07044804 | Brain-directed Treatment to Improve Language in Adolescents and Young Adults With Down Syndrome: the Efficacy of Transcranial Direct Current Stimulation Coupled With Linguistic Training. | NA | RECRUITING | Floriana Costanzo |
| NCT02493725 | A PROSPECTIVE, MULTI-CENTER, PHASE II STUDY TO EVALUATE THE SAFETY AND EFFICACY OF ECULIZUMAB IN SUBJECTS WITH GUILLAIN-BARRÉ SYNDROME | PHASE2 | COMPLETED | Chiba University |
| Trait / Disease | P-value | Effect Size | Risk Allele | Study |
|---|---|---|---|---|
| venous thromboembolism | 2e-22 | OR=3.57 [2.76-4.60] | rs6025-T | PMID:22672568 |
| venous thromboembolism | 1e-96 | OR=3.25 [2.91-3.64] | rs6025-T | PMID:25772935 |
| venous thromboembolism | 7e-50 | OR=3.5 [2.96–4.11] | rs6025-T | PMID:28373160 |
| inflammatory bowel disease | 9e-6 | beta=0.162 unit (decrease) | rs6025-? | PMID:37156999 |
| venous thromboembolism | 2e-1028 | beta=1.0904 unit (increase) | rs6025-T | PMID:36154123 |
| abnormal thrombosis | 4e-137 | OR=2.927 [2.715- 3.154] | rs6025-T | PMID:26908601 |
| total iron binding capacity | 2e-8 | beta=0.093 SD (decrease) | rs6025-T | PMID:33536631 |
| tissue factor pathway inhibitor amount | 2e-23 | beta=0.39 unit (decrease) | rs6025-T | PMID:34648354 |
| venous thromboembolism | 1e-188 | OR=2.39 [2.25-2.53] | rs6025-T | PMID:31420334 |
| venous thromboembolism | 1e-194 | rs6025-? | PMID:35285134 | |
| protein SEC13 homolog measurement | 1e-9 | beta=0.262 unit (decrease) | rs6025-T | PMID:34648354 |
| venous thromboembolism | 8e-811 | beta=1.1036 unit (increase) | rs6025-T | PMID:36154123 |
| venous thromboembolism | 4e-1051 | beta=1.0864 unit (increase) | rs6025-T | PMID:36154123 |
| ferritin measurement | 7e-37 | beta=0.15 SD (increase) | rs6025-T | PMID:33536631 |
| Antithrombotic agent use measurement | 3e-11 | beta=0.1479 unit (decrease) | rs6025-C | PMID:34594039 |
| venous thromboembolism | 1e-190 | rs6025-? | PMID:35285134 | |
| venous thromboembolism | 1e-300 | OR=2.5286865 [2.43-2.64] | rs6025-T | PMID:31676865 |
| venous thromboembolism | 2e-245 | beta=1.1108 unit (increase) | rs6025-T | PMID:36777996 |
| circulating fibrinogen levels | 2e-194 | rs6025-? | PMID:35285134 | |
| plasminogen activator inhibitor 1 measurement | 3e-190 | rs6025-? | PMID:35285134 | |
| Antithrombotic agent use measurement | 3e-11 | beta=0.14787269 unit (increase) | rs6025-T | PMID:31015401 |
| venous thromboembolism | 1e-188 | beta=0.8694 unit (increase) | rs6025-? | PMID:31420334 |
| Menorrhagia | 1e-21 | OR=0.77 [0.73-0.82] | rs6025-T | PMID:40069456 |
| D dimer measurement | 4e-11 | beta=0.257 unit (increase) | rs6025-T | PMID:33095540 |
| venous thromboembolism | 5e-27 | OR=5.775 [4.197-7.945] | rs6025-A | PMID:33592630 |
| peripheral vascular disease | 4e-12 | OR=0.64 | rs6025-C | PMID:33893285 |
| Iron deficiency anemia | 3e-10 | OR=0.79 | rs6025-T | PMID:38018286 |
| peripheral arterial disease | 2e-12 | OR=1.2 [1.14-1.26] | rs6025-T | PMID:31285632 |
| pulmonary embolism | 4e-30 | beta=0.7253895 unit (decrease) | rs6025-C | PMID:39789286 |
| venous thromboembolism | 2e-202 | OR=2.38 [2.25-2.52] | rs6025-? | PMID:38561338 |
| peripheral arterial disease | 7e-13 | OR=1.2 [1.15-1.25] | rs6025-T | PMID:34601942 |
| inflammatory bowel disease | 3e-8 | OR=1.1942284 | rs6025-G | PMID:26192919 |
| factor VIII measurement | 9e-193 | rs6025-? | PMID:35285134 | |
| deep vein thrombosis | 7e-154 | beta=0.99490005 unit (decrease) | rs6025-C | PMID:39789286 |
| factor XI measurement | 1e-189 | rs6025-? | PMID:35285134 |
| Year | Title | Authors | Journal | PMID |
|---|---|---|---|---|
| 2014 | Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A--an Israeli-German multicenter database study. | Kenet G et al. | Thrombosis research | 24485400 |
| 2019 | MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study. | Khidri FF et al. | BMC medical genetics | 31646966 |
| 2016 | Association Between Gene Polymorphisms on Chromosome 1 and Susceptibility to Pre-Eclampsia: An Updated Meta-Analysis. | Zhang G et al. | Medical science monitor : international medical journal of experimental and clinical research | 27348238 |
| 2025 | Genome-wide meta-analysis of heavy menstrual bleeding reveals 36 risk loci. | Thibord F et al. | Blood | 40324064 |
| 2014 | CYP2C9, VKORC1, CYP4F2, ABCB1 and F5 variants: influence on quality of long-term anticoagulation. | Nahar R et al. | Pharmacological reports : PR | 24911077 |
| 2024 | The incidence of the thrombophilic SNPs rs6025, rs1799963, rs2066865, rs2289252, and rs8176719 in chronic thromboembolic pulmonary hypertension. | Kvasnička J et al. | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis | 39150410 |
| 2020 | Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker-Induced Angioedema. | Maroteau C et al. | Clinical pharmacology and therapeutics | 32496628 |
| 2017 | Prevalence of F5 1691G>A, F2 20210G>A, and MTHFR 677C>T polymorphisms in Bosnian women with pregnancy loss. | Mahmutbegović E et al. | Bosnian journal of basic medical sciences | 28488549 |
| 2011 | Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. | Bergrem A et al. | British journal of haematology | 21564075 |
| 2014 | Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study. | Tinholt M et al. | BMC cancer | 25407022 |
| 2009 | Gluteal muscle activation during common therapeutic exercises. | Distefano LJ et al. | The Journal of orthopaedic and sports physical therapy | 19574661 |
| 2020 | Brain oscillation-synchronized stimulation of the left dorsolateral prefrontal cortex in depression using real-time EEG-triggered TMS. | Zrenner B et al. | Brain stimulation | 31631058 |
| 2024 | Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder: A Randomized Clinical Trial. | van 't Wout-Frank M et al. | JAMA psychiatry | 38446471 |
| 2025 | Who, when, where, and why: A systematic review of "late diagnosis" in autism. | Russell AS et al. | Autism research : official journal of the International Society for Autism Research | 39579014 |
| 2024 | Tailored Borneol-Modified Lipid Nanoparticles Nasal Spray for Enhanced Nose-to-Brain Delivery to Central Nervous System Diseases. | Wang G et al. | ACS nano | 39158142 |
| 2020 | Modulating the Blood-Testis Barrier Towards Increasing Drug Delivery. | Mao B et al. | Trends in pharmacological sciences | 32792159 |
| 2011 | Genetic predictors of response to photodynamictherapy. | Parmeggiani F et al. | Molecular diagnosis & therapy | 21913742 |
| 2025 | Structural network-specific effect of extreme capsule stimulation for drug-resistant focal epilepsy. | Cheng Y et al. | Brain : a journal of neurology | 40117381 |
| 2023 | Model-Informed drug development of gastroretentive release systems for sildenafil citrate. | Pinheiro de Souza F et al. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | 36516889 |
| 2023 | Design and evaluation of gastro-swelling/gastro-floating sustained-release tablets of brivaracetam for epilepsy therapy. | Hou Z et al. | International journal of pharmaceutics | 37572859 |
| 2025 | Association of blood biomarkers for neural injury with recent, frequent exposure to partnered sexual strangulation in young adult women. | Huibregtse ME et al. | The journal of sexual medicine | 40062485 |
| 2017 | Anaphylaxis and intimate behaviour. | Liccardi G et al. | Current opinion in allergy and clinical immunology | 28742538 |
| 2024 | Identification of TXN and F5 as novel diagnostic gene biomarkers of the severe asthma based on bioinformatics and machine learning analysis. | Shou L et al. | Autoimmunity | 39531229 |
| 2024 | Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus. | Mathey CM et al. | The Journal of allergy and clinical immunology | 38300190 |
| 2025 | Mepolizumab in patients with lymphoid-variant hypereosinophilic syndrome: A multicenter prospective study. | Catherine J et al. | The Journal of allergy and clinical immunology | 39788434 |
| 2022 | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach. | Ahmed MB et al. | Cells | 35805104 |
| 2024 | ADAMTS12 serves as a novel prognostic biomarker and promotes proliferation and invasion in gastric cancer. | Gao R et al. | Discover oncology | 39720953 |
| 2024 | Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers. | Gomar JJ et al. | JAMA psychiatry | 38922609 |
| Date | Patent # | Title | Assignee | Type |
|---|---|---|---|---|
| 2025-09-02 | 12404379 | Biaxially oriented polypropylene film | TOYOBO CO., LTD. | other |
| 2025-08-19 | 12391811 | Biaxially oriented polypropylene film | TOYOBO CO., LTD. | other |
| 2025-08-12 | 12388627 | Internet of Things security with multi-party computation (MPC) | INESC TEC—INSTITUTO DE ENGENHARIA DESISTEMAS E COMPUTADORES, TECNOLOGIA E CIÊNCIA | other |
| 2025-07-29 | 12372768 | Microscope objective | Evident Corporation | other |
| 2025-06-24 | 12339422 | Camera optical lens | AAC Optics (Suzhou) Co., Ltd. | other |
| 2025-06-17 | 12331297 | Coagulation factor V (F5) iRNA compositions and methods of use thereof | Alnylam Pharmaceuticals, Inc. | therapeutic |
| 2025-01-21 | 12202958 | Polypropylene film, metal layer laminated film using polypropylene film, and film capacitor | TORAY INDUSTRIES, INC. | diagnostic |
| 2025-01-21 | 12204077 | Camera optical lens | AAC Optics (Changzhou) Co., Ltd. | other |
| 2025-01-21 | 12206766 | Internet of things security with multi-party computation (MPC) | INESC TEC—INSTITUTO DE ENGENHARIA DESISTEMAS E COMPUTADORES, TECNOLOGIA E CIÊNCIA | other |
| 2024-12-31 | 12179762 | Vehicle control device, vehicle control method, and program | Hitachi Astemo, Ltd. | other |
| 2024-12-17 | 12169324 | Optical imaging lens group | Zhejiang Sunny Optics Co., Ltd | other |
| 2024-12-03 | 12158491 | Phase distortion measurement | KEYSIGHT TECHNOLOGIES, INC. | diagnostic |
| 2024-12-03 | 12158564 | Camera optical lens | AAC Optics (Suzhou) Co., Ltd. | other |
| 2024-10-29 | 12130412 | Camera optical lens | AAC Optics (Suzhou) Co., Ltd. | other |
| 2024-10-15 | 12117593 | Wide-angle lens including seven lenses of −−+++−+ or −++++−+ refractive powers | Dongguan Yutong Optical Technology Co., Ltd. | other |
| Partner | Score | Sources |
|---|---|---|
| SERPINA1 | 0.424 | cooccurrence, coexpression, textmining |
| MTHFR | 0.487 | textmining |
| F12 | 0.513 | coexpression, experimental, textmining |
| ALB | 0.542 | coexpression, experimental, textmining |
| F9 | 0.548 | coexpression, experimental, textmining |
| F8 | 0.656 | coexpression, experimental, database, textmining |
| F5 | 0.681 | coexpression, experimental, database, textmining |
| AHSG | 0.704 | coexpression, experimental, textmining |
| F11 | 0.728 | coexpression, experimental, database, textmining |
| F7 | 0.757 | coexpression, experimental, textmining |
| PROC | 0.76 | coexpression, experimental, database, textmining |
| KNG1 | 0.779 | coexpression, textmining |
| PROS1 | 0.801 | coexpression, textmining |
| F3 | 0.802 | textmining |
| F10 | 0.823 | coexpression, experimental, database, textmining |
| SERPINC1 | 0.837 | cooccurrence, coexpression, database, textmining |
| THBD | 0.846 | coexpression, textmining |
| FGB | 0.951 | coexpression, experimental, database, textmining |
| F2 | 0.999 | coexpression, experimental, database, textmining |
| SERPINA1 | 0.63 | coexpression, experimental, textmining |
| Interactors | Type | Method | PubMed | Score |
|---|---|---|---|---|
| Dlg4, Kcnab2 | association | anti bait coimmunoprecipitation | 19022416 | 0.64 |
| YWHAZ, Kcnab2 | association | tandem affinity purification | 16959763 | 0.35 |
| Syngap1, Kcnab2 | association | anti bait coimmunoprecipitation | 28706196 | 0.53 |
| Dlg4, Kcnab2 | association | anti bait coimmunoprecipitation | 28671696 | 0.64 |
| Syngap1, Kcnab2 | association | anti bait coimmunoprecipitation | 28671696 | 0.53 |
| Kcna2, Kcnab2 | physical association | anti bait coimmunoprecipitation | 21357749 | 0.4 |
| Dlg4, Kcnab2 | association | anti tag coimmunoprecipitation | 19455133 | 0.64 |
| Ywhaz, Kcnab2 | association | cosedimentation in solution | 19562802 | 0.35 |
| Dlg4, Kcnab2 | association | anti tag coimmunoprecipitation | 19455133 | 0.64 |
| SNCA, Kcnab2 | association | pull down | 18614564 | 0.35 |
| ITM2B, F5 | association | anti bait coimmunoprecipitation | 34446781 | 0.35 |
| TNFSF8, F5 | association | anti tag coimmunoprecipitation | 28514442 | 0.53 |
| MMRN1, F5 | association | anti tag coimmunoprecipitation | 28514442 | 0.53 |
| F5, FAM20C | phosphorylation reaction | protein kinase assay | 22582013 | 0.44 |
| KLRG2, F5 | association | anti tag coimmunoprecipitation | 28514442 | 0.53 |
| Gene A | Gene B | P(Interaction) | P(Wrong) |
|---|---|---|---|
| OLR1 | F5 | 0.99998471197731 | 1.04894452143785e-05 |
| MMRN1 | F5 | 0.999999932538696 | 2.97507119821375e-09 |
| TNFSF8 | F5 | 0.999861414830751 | 0.000126317025671767 |
| KLRG2 | F5 | 0.99983421966049 | 0.000156532208859474 |
| RYK | F5 | 0.820530313832648 | 0.17946072225659 |
| Gene A | Gene B | System | Throughput | PubMed |
|---|---|---|---|---|
| F10 | F5 | Reconstituted Complex | Low Throughput | 2303476 |
| CALR | F5 | Affinity Capture-Western | Low Throughput | 9525969 |
| PROS1 | F5 | Reconstituted Complex | Low Throughput | 10593904 |
| F5 | PROS1 | Reconstituted Complex | Low Throughput | 8428962 |
| F2 | F5 | Reconstituted Complex | Low Throughput | 9032460 |
| F5 | F5 | Co-crystal Structure | Low Throughput | 10586886 |
| POT1 | F5 | Affinity Capture-MS | Low Throughput | 20811636 |
| CCDC8 | F5 | Affinity Capture-MS | High Throughput | 24711643 |
| MMRN1 | F5 | Affinity Capture-MS | High Throughput | 26186194 |
| MED4 | F5 | Affinity Capture-MS | High Throughput | 25281560 |
| SRPK2 | F5 | Biochemical Activity | High Throughput | 26167880 |
| MMRN1 | F5 | Affinity Capture-MS | High Throughput | 28514442 |
| OLR1 | F5 | Affinity Capture-MS | High Throughput | 28514442 |
| KLRG2 | F5 | Affinity Capture-MS | High Throughput | 28514442 |
| TNFSF8 | F5 | Affinity Capture-MS | High Throughput | 28514442 |
| Drug | Type | Mechanism | Phase | Indication | Company |
|---|---|---|---|---|---|
| DROTRECOGIN ALFA (ACTIVATED) | Protein | Coagulation factor V inhibitor | Phase 4 | Multiple Organ Failure |
| Disease | Score | Evidence |
|---|---|---|
| thrombophilia due to activated protein C resistance | 0.795 | genomics_england, eva, uniprot_variants, uniprot_literature, clingen |
| congenital factor V deficiency | 0.769 | eva, genomics_england, orphanet, clingen, impc, europepmc |
| factor V deficiency | 0.766 | eva, genomics_england, uniprot_variants, uniprot_literature, europepmc |
| Ischemic stroke | 0.673 | eva, uniprot_literature, gwas_credible_sets, chembl, europepmc |
| hepatic vein thrombosis | 0.620 | eva, uniprot_literature, europepmc |
| stroke | 0.620 | eva, gwas_credible_sets, chembl, europepmc |
| habitual abortion | 0.617 | eva, uniprot_literature |
| Venous thrombosis | 0.584 | genomics_england, eva, europepmc |
| venous thromboembolism | 0.584 | gwas_credible_sets, europepmc |
| pulmonary embolism | 0.562 | gwas_credible_sets, chembl, europepmc |
| Thromboembolism | 0.561 | gwas_credible_sets, eva, europepmc |
| Sepsis | 0.556 | chembl, europepmc, expression_atlas |
| deep vein thrombosis | 0.543 | gwas_credible_sets, europepmc |
| Phlebitis | 0.535 | gwas_credible_sets, europepmc |
| Thrombophlebitis | 0.529 | gwas_credible_sets |
Companies with patents and/or clinical trials targeting F5:
Patents: 2
Patents: 2
Patents: 3
Patents: 1
Patents: 1
Patents: 1
Patents: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 2
Clinical Trials: 2
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
Clinical Trials: 1
| # | Source | Title | Authors | Year | Link |
|---|---|---|---|---|---|
| 1 | PubMed | Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A--an Israeli-German multicenter database study. | Kenet G et al. | 2014 | 24485400 |
| 2 | PubMed | MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study. | Khidri FF et al. | 2019 | 31646966 |
| 3 | PubMed | Association Between Gene Polymorphisms on Chromosome 1 and Susceptibility to Pre-Eclampsia: An Updated Meta-Analysis. | Zhang G et al. | 2016 | 27348238 |
| 4 | PubMed | Genome-wide meta-analysis of heavy menstrual bleeding reveals 36 risk loci. | Thibord F et al. | 2025 | 40324064 |
| 5 | PubMed | CYP2C9, VKORC1, CYP4F2, ABCB1 and F5 variants: influence on quality of long-term anticoagulation. | Nahar R et al. | 2014 | 24911077 |
| 6 | PubMed | The incidence of the thrombophilic SNPs rs6025, rs1799963, rs2066865, rs2289252, and rs8176719 in chronic thromboembolic pulmonary hypertension. | Kvasnička J et al. | 2024 | 39150410 |
| 7 | PubMed | Exome Sequencing Reveals Common and Rare Variants in F5 Associated With ACE Inhibitor and Angiotensin Receptor Blocker-Induced Angioedema. | Maroteau C et al. | 2020 | 32496628 |
| 8 | PubMed | Prevalence of F5 1691G>A, F2 20210G>A, and MTHFR 677C>T polymorphisms in Bosnian women with pregnancy loss. | Mahmutbegović E et al. | 2017 | 28488549 |
| 9 | PubMed | Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. | Bergrem A et al. | 2011 | 21564075 |
| 10 | PubMed | Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study. | Tinholt M et al. | 2014 | 25407022 |
| 11 | PubMed | Gluteal muscle activation during common therapeutic exercises. | Distefano LJ et al. | 2009 | 19574661 |
| 12 | PubMed | Brain oscillation-synchronized stimulation of the left dorsolateral prefrontal cortex in depression using real-time EEG-triggered TMS. | Zrenner B et al. | 2020 | 31631058 |
| 13 | PubMed | Virtual Reality and Transcranial Direct Current Stimulation for Posttraumatic Stress Disorder: A Randomized Clinical Trial. | van 't Wout-Frank M et al. | 2024 | 38446471 |
| 14 | PubMed | Who, when, where, and why: A systematic review of "late diagnosis" in autism. | Russell AS et al. | 2025 | 39579014 |
| 15 | PubMed | Tailored Borneol-Modified Lipid Nanoparticles Nasal Spray for Enhanced Nose-to-Brain Delivery to Central Nervous System Diseases. | Wang G et al. | 2024 | 39158142 |
| 16 | PubMed | Modulating the Blood-Testis Barrier Towards Increasing Drug Delivery. | Mao B et al. | 2020 | 32792159 |
| 17 | PubMed | Genetic predictors of response to photodynamictherapy. | Parmeggiani F et al. | 2011 | 21913742 |
| 18 | PubMed | Structural network-specific effect of extreme capsule stimulation for drug-resistant focal epilepsy. | Cheng Y et al. | 2025 | 40117381 |
| 19 | PubMed | Model-Informed drug development of gastroretentive release systems for sildenafil citrate. | Pinheiro de Souza F et al. | 2023 | 36516889 |
| 20 | PubMed | Design and evaluation of gastro-swelling/gastro-floating sustained-release tablets of brivaracetam for epilepsy therapy. | Hou Z et al. | 2023 | 37572859 |
| 21 | PubMed | Association of blood biomarkers for neural injury with recent, frequent exposure to partnered sexual strangulation in young adult women. | Huibregtse ME et al. | 2025 | 40062485 |
| 22 | PubMed | Anaphylaxis and intimate behaviour. | Liccardi G et al. | 2017 | 28742538 |
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| 29 | Intact | — | — | — | 19022416 |
| 30 | Intact | — | — | — | 16959763 |
| 31 | Intact | — | — | — | 28706196 |
| 32 | Intact | — | — | — | 28671696 |
| 33 | Intact | — | — | — | 21357749 |
| 34 | Intact | — | — | — | 19455133 |
| 35 | Intact | — | — | — | 19562802 |
| 36 | Intact | — | — | — | 18614564 |
| 37 | Intact | — | — | — | 34446781 |
| 38 | Intact | — | — | — | 28514442 |
| 39 | Intact | — | — | — | 22582013 |
| 40 | Intact | — | — | — | 17804407 |
| 41 | Intact | — | — | — | 33961781 |
| 42 | Biogrid | — | — | — | 2303476 |
| 43 | Biogrid | — | — | — | 9525969 |
| 44 | Biogrid | — | — | — | 10593904 |
| 45 | Biogrid | — | — | — | 8428962 |
| 46 | Biogrid | — | — | — | 9032460 |
| 47 | Biogrid | — | — | — | 10586886 |
| 48 | Biogrid | — | — | — | 20811636 |
| 49 | Biogrid | — | — | — | 24711643 |
| 50 | Biogrid | — | — | — | 26186194 |
| 51 | Biogrid | — | — | — | 25281560 |
| 52 | Biogrid | — | — | — | 26167880 |
| 53 | Biogrid | — | — | — | 32325033 |
| 54 | Biogrid | — | — | — | 31904090 |
| 55 | Biogrid | — | — | — | 32780723 |
| 56 | Biogrid | — | — | — | 31040226 |
| 57 | Biogrid | — | — | — | 37616343 |
| 58 | Biogrid | — | — | — | 36526897 |
| 59 | Biogrid | — | — | — | 37059927 |
| 60 | Biogrid | — | — | — | 37528093 |
| 61 | Biogrid | — | — | — | 40437099 |